Antibody design · Binder design · Protein Design

mBER

(Work in Progress)

A protein design framework for antibody binder design

Controllable de novo antibody design with million-scale experimental screening. mBER enables format specific binder design by leveraging structure templates and sequence conditioning in backprop design through AlphaFold-Multimer.

Documentation ↗ Paper ↗ Source code ↗ License ↗

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Job name

Target antigen PDB

Target chains Comma-separated if the target is bound across more than one chain, for example A,B.

Epitope hotspots (optional) Comma-separated target residues, for example A56,A57. Empty lets mBER bind anywhere on the target.

Designs to keep The run stops once this many trajectories have passed the iPTM/pLDDT filters.

Trajectories to attempt Upper bound on attempts if num_accepted is never reached.

Minimum iPTM

Minimum pLDDT

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Endpoint POST /api/mber/

Send JSON or standard form data. A GET request returns this tool's field schema.

API reference for mBER →