Antibody design · Protein Design · Binder design

Germinal

(Work in Progress)

Efficient generation of epitope-targeted de novo antibodies

Germinal is a pipeline for designing de novo antibodies against specified epitopes on target proteins. The pipeline follows a 3-step process: hallucination based on ColabDesign, selective sequence redesign with AbMPNN, and cofolding with a structure prediction model. Germinal is capable of designing both nanobodies and scFvs against user-specified residues on target proteins.

Documentation ↗ Paper ↗ Source code ↗ License ↗

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Job name

Target antigen PDB

Target chain

Epitope hotspots Comma-separated target residues that define the epitope, for example A56,A57,A58.

Binder format

Trajectories to run Hallucination trajectories attempted; most are discarded by the filters.

Designs to keep The run stops once this many designs have passed every filter.

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Endpoint POST /api/germinal/

Send JSON or standard form data. A GET request returns this tool's field schema.

API reference for Germinal →