Antibody design · Sequence prediction
AntiFold
(Work in Progress)
Structure-based antibody design using inverse folding
AntiFold predicts sequences which fit into an input antibody variable domain structure. The tool outputs residue log-likelihoods in CSV format, and can sample sequences to a FASTA format directly. Sampled sequences show high structural agreement with experimental structures. AntiFold is based on the ESM-IF1 model and is fine-tuned on solved and predicted antibody structures from SAbDab and OAS.